SELECTED PUBLICATIONS
2023
Sanil Patel, Njeri Z. R. Sparman, Douglas Arneson, Alexandra Alvarsson, Luís C. Santos, Samuel J. Duesman, Alessia Centonze, Ephraim Hathaway, In Sook Ahn, Graciel Diamante, Ingrid Cely, Chung Hwan Cho, Noble Kumar Talari, Abha K. Rajbhandari, Leigh Goedeke, Peng Wang, Atul J. Butte, Cédric Blanpain, Karthickeyan Chella Krishnan, Aldons J. Lusis, Sarah A. Stanley, Xia Yang & Prashant Rajbhandari*. Mammary duct luminal epithelium controls adipocyte thermogenic programme. *Senior and corresponding author. 2023. Nature. 620, pages192–199. 10.1038/s41586-023-06361-5
Volume 620 Issue 7972,
3 August 2023
A PPARγ-lncRNA axis modulates thermoneutral remodeling of white adipose tissue
Zhengyi Zhang, Ya Cui, Vivien Su, Marc Tol, Lijing Cheng, Xiaohui Wu, Jason Kim, Prashant Rajbhandari, Wei Li, Peter Tontonoz, Claudio Villanueva, and Tamer Sallam. A PPARγ-lncRNA axis modulates thermoneutral remodeling of white adipose tissue.2023.The Journal of Clinical Investigation (Accepted)
Sanil Patel, Njeri Sparman, Jeixin Wang, Julian P. Whitelegge, Susan Fried, Marcus Seldin, Shinya Wilfried Ellmeier, Peter Tontonoz, and Prashant Rajbhandari*. Transcription factor PATZ1 promotes white adipogenesis by controlling promoter regulatory loci of adipogenic factors. *Senior and corresponding author. 2023 (Nature Communications) (Under Revision)
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa Siddiq, Prashant Rajbhandari, Donald K. Scott, Adolfo Garcia-Ocana, and Geming Lu. Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Activity. 2023. Genome Medicine 15:30 DOI 10.1186/s13073-023-01179-2
2022
Lara Bideyan, Maykel López Rodríguez, Christina Priest, John P. Kennelly, Prashant Rajbhandari, An-Chieh Feng, Sergei G. Tevosian, Stephen T. Smale, Peter Tontonoz. Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs. 2022. Genes & Development 36:1-16 doi:10.1101/gad.350145.122
Samuel J. Duesman, Neha Ogale, Sanutha Shetty, Sanil Patel, Farzana Mohamed, Njeri Sparman, Prashant Rajbhandari, & Abha Karki Rajbhandari. .2022. Frontiers in Behavioral Neuroscience. doi: 10.3389/fnbeh.2022.995573
2021
Guo, F., Seldin, M., Peterfy, M., Charugundla, S., Zhou, Z., Lee, S. D., Mouton, A., Rajbhandari, P., Zhang, W., Pellegrini, M., Tontonoz, P., Lusis, A. J., and Shih, D. M. (2021) NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. Sci Rep 11, 16409
2020
Zhou, Z, Timothy M. Moore, Brian G. Drew,Vicent Ribas, Mete Civelek, Frode Norheim, Marcus M. Seldin, Kate A. Whitney, Ellen Lester, Britany R. Reddish, Laurent Vergnes, Karen Reue, Prashant Rajbhandari, Peter Tontonoz, Jason Lee, Sushil K. Mahata, Sylvia C. Hewitt, Orian Shirihai, Kerrin Small, Markku Laakso, Sindre Lee, Christian A. Drevon, Kenneth S. Korach, Aldons J. Lusis, Andrea L. Hevener. Estrogen receptor a controls energy homeostasis in white and brown adipose tissue by regulating Polg1 and mitochondrial remodeling. Science Translational Medicine. 12, eaax8069 (2020).
Liu, Q., Yu, J., Wang, L., Tang, Y., Zhou, Q., Ji, S., Wang, Y., Santos, L., Haeusler, R. A., Que, J., Rajbhandari, P., Lei, X., Valenti, L., Pajvani, U. B., Qin, J., and Qiang, L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. Jourmal of Hepatology. 2020; S0168-8278(20)30124-0 PMID: 32135178
2018
Rajbhandari, P., Thomas, B, Feng, A., Hong, C, Vergnes, L., Wang, J., Sallam, T., Wang, B., Sandhu, J., Seldin, MM., Lusis, AJ., Fong. L., Young, SG., Reue, K., Smale, T., and Tontonoz, P. Interleukin-10 Signaling Alters Chromatin Architecture in Adipose to Limit Thermogenesis and Energy expenditure. Cell. 2018; 172, 1, 218-233.e1; e217doi.org/10.1016/j.cell.2017.11.019
January 25, 2018
February 2018
EPIGENETIC REGULATION OF MACROPHAGE CHOLESTEROL EFFLUX AND ATHEROGENESIS BY THE NONCODING RNA MEXIS.
Seldin, MM., Koplev,S., Rajbhandari, P., Vergnes, L., Rosenberg, GM., Gharakhanian, R., Che, N., Pan,C., Mäkinen, S., Meng, Y., Shih, DM., Civelek, M., Parks. BW., Kim, ED., Norheim, F., Krishnan, KC., Hasin-Brumshtein,Y., Mehrabian, M., Laakso, M., Drevon, CA., Koistinen, HA., Tontonoz, P., Reue, K., Cantor, RM., Björkegren, JLM., Lusis, AJ. A strategy for discovery of endocrine interactions with application to whole-body metabolism. Cell Metabolism. 2018; 27, 5, 1138-1155.e
Sallam, T., Jones, M., Thomas, B., Wu, X., Gilliand,T., Qian, K., Eskin, A., Casero, D., Zhang, Z., Sandhu, J., Salisbury, A., Rajbhandari, P., Civelek, M., Hong, C., Ito, A., Liu, X., Daniel, B., Lusis, AJ., Whitelegge, J., Nagy, L., Castrillo, A., Smale, S., and Tontonoz, P. Epigenetic regulation of macrophage cholesterol efflux and atherogenesis by the noncoding RNA MeXis. Nature Medicine. 2018; 24(3):304-312
2017
Wang, J, Rajbhandari, P, Damianov, A, Han, A, Waki, A, Villanueva, C, Nielsen, R, Mandrup, S., Reue, K, Young, SG, Whitelegge, J, Saez, E, Black, DL, Tontonoz, P. The paraspeckle protein Pspc1 promotes the differentiation-dependent nuclear export of adipogenic RNAs. Journal of Clinical Investigation. 2017 Mar; 127(3):987-1004.
Zhang, Li, Rajbhandari, P., Priest, C., Wu, X., Vallim, TA., Sallam, T., Temel, R. Sallam, T., and Tontonoz, P. Inhibition of Cholesterol Biosynthesis Through RNF145-mediated Ubiquitination of SCAP. eLIFE. 2017; 6:e28766 DOI: 10.7554/eLife.28766
2016
Song NJ, Rajbhandari P*, Choi S*, Chang SH, Kim S, Vergnes, L, Kwon SM, Yoon JH, Lee S, Ku JM, Lee JS, Reue K, Koo SH, Tontonoz P, Park KW. Prdm4 induction by the small molecule butein promotes white adipose tissue browning. Nat. Chem. Biol. 2016 Jul;12(7):479-81. *Co-authors.
2019
*First report of adipocyte heterogeniety by snRNA-seq
*COVER ARTICLE
Rajbhandari, P.*, Arnenson, D., Hart, SH., Ahn, I-S., Diamante, G., Santos, LK., Feng, A-C., Thomas, BH., Vergenes, L., Lee, SD. Reue, K., Smale, ST., Yang, X, and Tontonoz, P.*. Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes. eLife. 2019;8:e49501 DOI: 10.7554/eLife.49501
*Corresponding authors
Lee,S.D, Priest,C, Bjursell, M., Gao,J., Arneson, D.V., Ahn, I-S., Diamante,G., van Veen,E., Massa, M.G., Calkin,A.C., Kim,J., Andersén,H., Rajbhandari,P., Porritt,M.,Carreras,A., Ahnmark, A., Seeliger, F., Maxvall, I., Eliasson,P., Althage, M., Åkerblad, P., Lindén, D., Cole, T.A., Lee, R., Boyd, H., Bohlooly-Y, M., Correa, S., Yang, X., Tontonoz, P., and Hong, C. IDOL regulates systemic energy balance through control of neuronal VLDLR expression. Nature Metabolism. 2019; https://doi.org/10.1038/s42255- 019-0127-7
Blázquez-Medela, A.M., Jumabay, M.,
Rajbhandari, P., Sallam, T., Vergnes, L., Yao, L., Yao, Y., Fogelman, A.M., Tontonoz, P., Reue, K., Lusis, A.J., Wu, X., Boström, K.I. Adipocyte-Specific Noggin Deletion Promotes Obesity in Mice. Molecular Metabolism. 2019; pii: S2212-8778(18)31188-8. doi: 10.1016/j.molmet.2019.04.004.
Loss of Tle3 promomtes mitochondrial program in beige
adipocytes and improves glucose metabolism
Pearson, S., Loft, A., Rajbhandari, P., Simcox, J., Lee, S., Donato, A., Tontonoz, P., Mandrup, S., and Villaneuva, C. Loss of TLE3 Promotes Mitochondrial Program in Beige Adipocytes and Improves Glucose Metabolism. Genes & Development. 2019; 33:1-16, doi:10.1101/gad.321943.118