SELECTED PUBLICATIONS
Developmental Cell (Submitted)
Sanil Patel, Njeri Sparman, Shani Sadeh, Jeixin Wang, Julian P. Whitelegge, Susan Fried, Marcus Seldin, Shinya Sakaguchu, Wilfried Ellmeier, Peter Tontonoz, and Prashant Rajbhandari*. Transcriptional control of adipogenesis by PATZ1. 2022. *Corresponding and senior author.
https://www.biorxiv.org/content/10.1101/2022.05.24.493273v1
Luis C. Santos, Douglas Arneson, Alexandra Alvarsson, Karthickeyan Chella Krishnan, Alessia Centzone, Sanil Patel, Shani Sadeh, In Sook Ahn, Graciel Diamante, Ingrid Cely, Atul J. Butte, Cédric Blanpain, Sarah A. Stanley, Aldons J. Lusis, Xia Yang, Prashant Rajbhandari*. 2021 bioRxiv. https://www.biorxiv.org/content/10.1101/2020.11.14.378687v3; *Senior and corresponding author
Nature (Under Revision)
Guo, F., Seldin, M., Peterfy, M., Charugundla, S., Zhou, Z., Lee, S. D., Mouton, A., Rajbhandari, P., Zhang, W., Pellegrini, M., Tontonoz, P., Lusis, A. J., and Shih, D. M. (2021) NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. Sci Rep 11, 16409
August 5, 2020
March 3, 2020
Zhou, Z, Timothy M. Moore, Brian G. Drew,Vicent Ribas, Mete Civelek, Frode Norheim, Marcus M. Seldin, Kate A. Whitney, Ellen Lester, Britany R. Reddish, Laurent Vergnes, Karen Reue, Prashant Rajbhandari, Peter Tontonoz, Jason Lee, Sushil K. Mahata, Sylvia C. Hewitt, Orian Shirihai, Kerrin Small, Markku Laakso, Sindre Lee, Christian A. Drevon, Kenneth S. Korach, Aldons J. Lusis, Andrea L. Hevener. Estrogen receptor a controls energy homeostasis in white and brown adipose tissue by regulating Polg1 and mitochondrial remodeling. Science Translational Medicine. 12, eaax8069 (2020).
Liu, Q., Yu, J., Wang, L., Tang, Y., Zhou, Q., Ji, S., Wang, Y., Santos, L., Haeusler, R. A., Que, J., Rajbhandari, P., Lei, X., Valenti, L., Pajvani, U. B., Qin, J., and Qiang, L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. Jourmal of Hepatology. 2020; S0168-8278(20)30124-0 PMID: 32135178
*First report of adipocyte heterogeniety by snRNA-seq
*COVER ARTICLE
Rajbhandari, P.*, Arnenson, D., Hart, SH., Ahn, I-S., Diamante, G., Santos, LK., Feng, A-C., Thomas, BH., Vergenes, L., Lee, SD. Reue, K., Smale, ST., Yang, X, and Tontonoz, P.*. Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes. eLife. 2019;8:e49501 DOI: 10.7554/eLife.49501
*Corresponding authors
November 7, 2019
November 2, 2019
Lee,S.D, Priest,C, Bjursell, M., Gao,J., Arneson, D.V., Ahn, I-S., Diamante,G., van Veen,E., Massa, M.G., Calkin,A.C., Kim,J., Andersén,H., Rajbhandari,P., Porritt,M.,Carreras,A., Ahnmark, A., Seeliger, F., Maxvall, I., Eliasson,P., Althage, M., Åkerblad, P., Lindén, D., Cole, T.A., Lee, R., Boyd, H., Bohlooly-Y, M., Correa, S., Yang, X., Tontonoz, P., and Hong, C. IDOL regulates systemic energy balance through control of neuronal VLDLR expression. Nature Metabolism. 2019; https://doi.org/10.1038/s42255- 019-0127-7
February 2018
Seldin, MM., Koplev,S., Rajbhandari, P., Vergnes, L., Rosenberg, GM., Gharakhanian, R., Che, N., Pan,C., Mäkinen, S., Meng, Y., Shih, DM., Civelek, M., Parks. BW., Kim, ED., Norheim, F., Krishnan, KC., Hasin-Brumshtein,Y., Mehrabian, M., Laakso, M., Drevon, CA., Koistinen, HA., Tontonoz, P., Reue, K., Cantor, RM., Björkegren, JLM., Lusis, AJ. A strategy for discovery of endocrine interactions with application to whole-body metabolism. Cell Metabolism. 2018; 27, 5, 1138-1155.e
EPIGENETIC REGULATION OF MACROPHAGE CHOLESTEROL EFFLUX AND ATHEROGENESIS BY THE NONCODING RNA MEXIS.
FEBRUARY 2018
Sallam, T., Jones, M., Thomas, B., Wu, X., Gilliand,T., Qian, K., Eskin, A., Casero, D., Zhang, Z., Sandhu, J., Salisbury, A., Rajbhandari, P., Civelek, M., Hong, C., Ito, A., Liu, X., Daniel, B., Lusis, AJ., Whitelegge, J., Nagy, L., Castrillo, A., Smale, S., and Tontonoz, P. Epigenetic regulation of macrophage cholesterol efflux and atherogenesis by the noncoding RNA MeXis. Nature Medicine. 2018; 24(3):304-312
Song NJ, Rajbhandari P*, Choi S*, Chang SH, Kim S, Vergnes, L, Kwon SM, Yoon JH, Lee S, Ku JM, Lee JS, Reue K, Koo SH, Tontonoz P, Park KW. Prdm4 induction by the small molecule butein promotes white adipose tissue browning. Nat. Chem. Biol. 2016 Jul;12(7):479-81. *Co-authors.
JULY 2016
Wang, J, Rajbhandari, P, Damianov, A, Han, A, Waki, A, Villanueva, C, Nielsen, R, Mandrup, S., Reue, K, Young, SG, Whitelegge, J, Saez, E, Black, DL, Tontonoz, P. The paraspeckle protein Pspc1 promotes the differentiation-dependent nuclear export of adipogenic RNAs. Journal of Clinical Investigation. 2017 Mar; 127(3):987-1004.
February 2018
Zhang, Li, Rajbhandari, P., Priest, C., Wu, X., Vallim, TA., Sallam, T., Temel, R. Sallam, T., and Tontonoz, P. Inhibition of Cholesterol Biosynthesis Through RNF145-mediated Ubiquitination of SCAP. eLIFE. 2017; 6:e28766 DOI: 10.7554/eLife.28766
FEBRUARY 2018
Blázquez-Medela, A.M., Jumabay, M.,
Rajbhandari, P., Sallam, T., Vergnes, L., Yao, L., Yao, Y., Fogelman, A.M., Tontonoz, P., Reue, K., Lusis, A.J., Wu, X., Boström, K.I. Adipocyte-Specific Noggin Deletion Promotes Obesity in Mice. Molecular Metabolism. 2019; pii: S2212-8778(18)31188-8. doi: 10.1016/j.molmet.2019.04.004.
Loss of Tle3 promomtes mitochondrial program in beige
adipocytes and improves glucose metabolism
Pearson, S., Loft, A., Rajbhandari, P., Simcox, J., Lee, S., Donato, A., Tontonoz, P., Mandrup, S., and Villaneuva, C. Loss of TLE3 Promotes Mitochondrial Program in Beige Adipocytes and Improves Glucose Metabolism. Genes & Development. 2019; 33:1-16, doi:10.1101/gad.321943.118
Rajbhandari, P., Thomas, B, Feng, A., Hong, C, Vergnes, L., Wang, J., Sallam, T., Wang, B., Sandhu, J., Seldin, MM., Lusis, AJ., Fong. L., Young, SG., Reue, K., Smale, T., and Tontonoz, P. Interleukin-10 Signaling Alters Chromatin Architecture in Adipose to Limit Thermogenesis and Energy expenditure. Cell. 2018; 172, 1, 218-233.e1; e217doi.org/10.1016/j.cell.2017.11.019